The release form of the drug Nolvadex is a package (can) with 50 tablets, each containing 20 mg.
Nolvadex is a brand for drugs based on the active ingredient tamoxifen citrate. It is a nonsteroidal substance that has anti-estrogenic properties. This property is explained by the ability of a substance to compete with estrogen in various tissues. In medical practice, this effect is very beneficial in treating patients with tumors caused by the action of estrogen.
Male bodybuilders find Nolvadex very effective in combating the effects of steroids with a strong level of aromatization, which leads to an increase in estrogen levels. Without correction or post course therapy (PCT), gynecomastia and the formation of fat deposits forming a womanlike image can develop. Nolvadex, to be more exact – Tamoxifen citrate, works by blocking estrogen receptors, as a result of the use of Nolvadex, the negative development of the breast on the breast decreases significantly and can stop altogether.
The drug is almost non-toxic and gives almost no negative effects. The drug fits well with most of the anabolic courses, as a counterweight to possible side effects. It should be noted that Nolvadex is able to slow the progress of genomicostomy during the steroid course. This can be explained by the fact that estrogen plays the task in maintaining open androgen receptors. Regardless, Nolvadex is considered the most well-known anti-estrogen used by male athletes.
Nolvadex working principle
Nolvadex (Tamoxifen citrate) does not affect the level of estrogen in the blood, because its mechanism of action is reduced to blockade of different types of estrogen receptors. Thus, we can speak of Tamoxifen citrate as non-selective (non-selective). Nolvadex binds to estrogen receptors throughout the body. By blocking receptors throughout the body, it helps the body begin to restore its own testosterone. It is important to note that Nolvadex is able to block the estrogen receptors in the pituitary to a lesser extent than Clomid.
Nolvadex intake, absorption and elimination
When taken orally, the drug is rapidly absorbed, and after 5–7 hours the greatest concentration in the blood is done. The drug interacts with 99% of blood proteins (albumin). Removal of the drug results in a two-phase: initial T 1/2 from 8 to 14 h, the final T 1/2 – 7 days.
The start of taking Nolvadex accounts for 2 weeks of the steroid cycle, and ends 2-3 weeks after the end of the cycle, the average dose of 10-20 mg per day.
Note the common misconception that antiestrogens should be drunk after a cycle. This is not true. The level of estrogen rises at the end of the first week of the cycle of taking anabolic drugs, so from this point on, you need to start taking. If anabolic drugs are used that are slightly susceptible to aromatization, then the need for aromatase inhibitors during the course disappears, and Tamoxifen citrate Nolvadex is included only at the end of the course.
This drug is included in the list of prohibited doping agents. The detection time is 3-6 months depending on the detection method.